PI3K Inhibitors have emerged as a popular treatment for hormone-receptor-positive breast cancers, improving progression-free survival rates for those with ER+ breast cancer.

Randomized phase III studies have confirmed the efficacy of agents targeting the PI3K/AKT/mTOR axis, leading to the approval of mTOR inhibitors, everolimus, and temsirolimus, for an increasing array ...

HOUSTON -- Two-thirds of patients with PI3K-mutant brain metastases responded to the maximum tolerated dose (MTD) of the small-molecule inhibitor paxalisib plus radiation therapy (RT), a small ...

If looking at the entire PI3K-a target market for breast cancer, it's 36% of patients who express this, but the focus of the PI3Ka-H1047R type brings it to 15%.

Researchers unveil PI3K enzyme's dual accelerator and brake mechanisms Date: April 24, 2024 Source: Tohoku University Summary: The enzyme PI3K plays a critical role in cell migration.

The phosphoinositide 3-kinase (PI3K) pathway plays an integral role in many cellular processes and is frequently altered in cancer, contributing to tumor growth and survival. Small molecule inhibitors ...

The PI3K-delta isoform is known to support the function of T regulatory (Treg) cells, which can dampen an immune response. In samples collected from the patients, the team found AMG319 treatment ...

Patient survival is both an efficacy and safety marker, the FDA says. And for these PI3K inhibitors, which have shown favorable effects on anti-tumor efficacy but not eventually on prolonging life ...

Synnovation’s attempt to crack the PI3K puzzle has resulted in a molecule that targets the alpha form of the kinase and, according to the biotech, “is differentiated from competitor molecules ...

Mutations in the PI3K pathway predict aspirin response, broadening its use to more patients. Aspirin improved disease-free survival in some groups but increased severe side effects compared to placebo ...