Taken together, we showed that knockout of PDK1 indirectly alters the PI3K/PDK1 signaling axis by regulating gene transcription of Lyn, PI3K subunits and phosphoinositide-modifying enzymes.

Rabbit polyclonal antibodies against AKT, pAKT (Ser473), caspase 3 and 9, Cbl, JAK2, pJAK2(Tyr1007/1008), Lyn, pLyn(Tyr396), Hck, and PARP, PI3K p85 STAT5, pSTAT5(Tyr694), were obtained from Cell ...

The discovery of phosphatidylinositol 3-kinase (PI3K) changed the way we view and understand growth-factor signaling. From early on, it became clear that PI3K plays an important role in many ...

Under the amended agreement, Infinity continues to retain full worldwide rights to IPI-145, a potent, oral inhibitor of PI3K-delta and PI3K-gamma, as well as worldwide rights to any future product ...

And that followed a similar decision by Secura Bio regarding its FL indication for PI3K drug Copiktra (duvelisib) – which is also approved for chronic lymphocytic leukaemia (CLL) – last December.