The ability to generate lung and airway epithelial cells from human pluripotent stem cells (hPSCs) would have applications in regenerative medicine, modeling of lung disease, drug screening and ...

we investigated a coculture system of human distal lung epithelial cell lines (A549 and NCI H441) and primary human pulmonary microvascular endothelial cells (HPMEC). The cells were allowed to ...

It prevents lung cells from dividing when they need to be replaced. And senescent cells secrete mediators that further promote fibrosis. Since this effect also plays a role in cancer, the ...

Original-Publikation: Lehmann, M. et al. (2017): Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo. European Respiratory Journal ...

“Epithelial cells in the lung are typically envisioned as supporting respiratory functions, while MHC-II is understood to connect immune cells to immune cells, so the finding that MHC-II on lung ...

In their second paper, "Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice," CReM researchers targeted the lung air sacks, known as alveoli. Kotton and his ...

Lung cancer remains the world’s deadliest cancer, and cigarette smoke is its chief culprit. Chemicals in tobacco, such as ...

the part of the study where the engineered lung mesenchymal cells are combined with lung epithelial cells in culture dishes (so called "recombinants") is particularly exciting as this resulted in ...

"Our data suggest that mucins play a key role in restricting SARS-CoV-2 infection by acting as a barrier to viruses that are attempting to access our lung epithelial cells," said Scott Biering ...

For the study, the researchers looked at the two main cell types that make up the alveolar epithelium in living mice. Alveolar epithelial type 1 cells, which line lung tissues, are crucial to the ...

indicating that the lung environment supports B cell development. The findings fundamentally change the understanding of the immune and epithelial interactions that are crucial for foetal lung ...

compared the chemical composition of cannabis smoke and cannabis vapor (i.e., the aerosol produced by vaping cannabis), as well as their in vitro effects on human lung epithelial cells ...