Hepatocytes, as the most abundant cell type in liver, are a potent source of fibrogenic ... that stellate cell activation generates hepatic fibrosis. The most potent stimulus to collagen I ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis ... membrane-type matrix. However, numerous in vivo and in vitro studies indicate that in response to liver injury ...

Our livers contain many different types ... cell types is required for tissue repair following injury. This suggests these cells may be useful as new therapeutic targets for various liver conditions.

Scientists at Massachusetts General Hospital have revealed how chronic liver injury alters hepatic stellate cells (HSCs), triggering the formation of fibrotic scarring in the liver. The researchers ...

In terms of death risk, liver cancer is one of ... standard of care appropriate for their type of chronic liver disease. Finally, they only used the Fibrosis-4 score method to look at fibrosis ...

One emerging approach involves targeting liver sinusoidal endothelial cell (LSEC ... and lower levels of fibrosis markers, such as hyaluronic acid and procollagen type III. In terms of metabolic ...

The authors found that statin use appeared to decrease the “10-year-cumulative incidence” of liver ... for their type of chronic liver disease. Finally, they only used the Fibrosis-4 score ...

In the early stages, fatty liver may be asymptomatic, with most people unaware they have it. However, continued fat buildup ...

Non-Alcoholic Fatty Liver Disease (NAFLD ... also succeeded in reducing the level of collagen type 1 in XL-2 cells in an in-vitro fibrosis model. The Company attributes the positive test results ...