Do lipids or the disruption of lipid metabolic pathways trigger non-apoptotic RCD pathways in unusual ways, or perhaps cause new types of non-apoptotic RCD? Can diseases of lipid metabolism teach ...

Surveillance pathway tells cells when they run low on lipids Date: May 18, 2022 Source: UT Southwestern Medical Center Summary: Researchers have discovered a molecular pathway that allows cells to ...

The paper is published in Cell Metabolism. A collaborative Stony Brook University research team has discovered a novel metabolic pathway of the lipid ceramide, which is involved in cell death.

The RHBDL4-SREBP-1c pathway, uncovered in this study, represents a lipid homeostasis mechanism regulated by fatty acids. This groundbreaking discovery is anticipated to pave the way for developing ...

Since the oxidation of fatty acids in this cell death pathway, was of paramount importance, multiple studies were performed to describe, in greater detail, the source and nature of lipid peroxides.

regulates lipid metabolism, which is important for providing energy to T cells. The mechanism by which these pathways determine T cell function, however, remains unknown. In recent work published ...

such as proteins and lipids. That is why we were amazed to find that in cells lacking either glutathione or glutathione peroxidase 4, a distinctive signaling pathway is engaged, which causes cell ...

The results indicate that the complexity of sterol metabolism could have resulted from the need to balance lipid interactions required for membrane organization "This has been one of my favorite ...

UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The ...

Glutathione can directly neutralize ROS such as lipid peroxides, and also plays a major role in xenobiotic metabolism. Xenobiotics are toxins that the body is exposed to. Exposure of the liver to ...

and they analyzed the role of the TGF-β signaling pathway in regulating lifespan, immunity, and lipid metabolism in Caenorhabditis elegans. The study is published in the journal Nature ...