The relative lack of biochemical data on many large subunit proteins ... the factor binding center and subunit interface. In short, the RNAs and proteins of ribosomal particles are inseparable ...

Peter Shen, a postdoctoral researcher in Frost’s lab, isolated RQCs from yeast cells and used cryo-electron microscopy to develop three-dimensional images of their interactions with large ribosomal ...

The rRNA structures also provide binding sites for ribosomal proteins, which help stabilize the overall structure of the ribosome. One of the most remarkable features of rRNA is its catalytic activity ...

"Ribosomes are very large macromolecular machines that very ... subunit composition or post-translational modifications to ribosomal subunit proteins, or a combination of both." ...

a 30S small subunit and a 50S large subunit. The 30S subunit contains a 16S ribosomal RNA (rRNA) molecule, while the 50S subunit harbors 23S and 5S rRNA molecules. In contrast, eukaryotic cells ...