【导读】用于信使核糖核酸（mRNA）递送的脂质纳米颗粒（LNPs）已取得显著进展，但脂质纳米颗粒介导的脱氧核糖核酸（DNA）递送在临床上仍面临诸多挑战。1月13日，美国贝勒医学院研究人员在期刊《Molecular Cancer》上发表了研究论文，题为 ...

该研究筛选到了一种胎盘亲和性LNP——LNP-55，LNP-55递送VEGF mRNA能够高效靶向胎盘，并有效改善先兆子痫母鼠以及胎鼠的健康水平。 在正常妊娠过程中，胎盘的绒毛滋养层细胞会侵入子宫肌层，重塑并扩张螺旋动脉，从而在绒毛膜（母-胎界面）处创造出低阻力 ...

随着新冠疫苗和2023年诺贝尔生理学或医学奖的颁布，mRNA这个分子生物学词汇已妇孺皆知。mRNA即信使RNA，如果说基因产生“指令”，决定我们身体的性状，那mRNA就是传递基因“指令”的“信使”，它把“指令”翻译成各种蛋白质，从而在体内发挥各种生物 ...

A new study has introduced an innovative approach to CAR-T therapy that could address some of the current challenges in ...

PRX是维肽瀛联合日本熊本大学的一款针对核酸药物递送的纳米分子。该分子不仅展现出极其稳定的递送效率，并可实现多器官精准靶向，与其他同类技术相比，生产工艺简单、安全性高，具有更具前景的应用空间。目前该分子已验证了多种核酸类型的递送验证，结果令人鼓舞。 返回搜狐，查看更多 ...

Using its proprietary technology, Esphera SynBio causes the production of modified nanomedicines within patients upon delivery of LNP/mRNA vaccines. These in situ produced nanomedicines can have ...

Esphera SynBio, a pre-clinical stage synthetic biology company, has launched a new project aimed at enhancing the efficacy of ...

PopVax awarded $2M for its patch-delivered mRNA influenza vaccine in collaboration with LTS Lohmann as part of BARDA’s Patch Forward Prize.

Vancouver-based Genevant Sciences, a leading nucleic acid delivery company with world-class platforms and an expansive lipid ...

The investment firm noted that Moderna (MRNA) and Pfizer (PFE), along with Pfizer (PFE) partner BioNTech (BNTX), were being sued for patent infringement by Arbutus (NASDAQ:ABUS) over LNP ...