Upstream kinases that have recently been identified include the tumour suppressor LKB1 and calmodulin-dependent kinase kinase-β. Mutations in the γ2 isoforms that cause human heart disease ...

These include NSCLC tumors that carry mutations in both the KRAS and LKB1 genes. Patients with this type of cancer, known as KL mutant NSCLC, have limited treatment options if their tumors don’t ...

LKB1-mut has been shown as a major genetic driver of primary resistance to immune checkpoint inhibitors. Here this group reports the identification of the LKB1-IAP-JAK dynamic complex as a ...