The patients came in with high cholesterol. And it was the kind that clings stubbornly to arteries and shadows families for generations. They walked into a clinical trial and left, perhaps, with a ...

Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures, and commercializes high-quality medicines for the treatment of oncology, ...

When the amount of cholesterol in the blood is too high, hypercholesterolemia can develop, causing serious damage to the ...

Study deciphers the molecular handshake between LDL receptors and apoB100, shedding light on cholesterol metabolism and its role in cardiovascular disease. Study: Structure of apolipoprotein B100 ...

Back to Healio A novel agent demonstrated a dose-dependent relationship with lectin-like oxidized LDL receptor-1 suppression, a mechanism to lower inflammatory and lipid risk, and was well ...

PCSK9 normally acts on the liver’s LDL receptors by lowering the liver’s ability to remove LDL from the blood. Repatha is a PCSK9 inhibitor, which means that it blocks the action of the PCSK9 ...

Two of the agents, alirocumab and evolocumab, are monoclonal antibodies that inhibit PCSK9, which binds to LDL receptors on the surface of liver cells. PCSK9 prevents the LDL receptor from being ...