The kinetochore is a large proteinaceous structure that mediates interactions between chromosomal DNA and spindle-microtubule polymers. More than 80 kinetochore proteins have been identified using ...

Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. "When you understand a ...

Here lies the kinetochore, a complicated assembly of proteins that binds to thread-like structures, the microtubules. As mitosis progresses, the kinetochore gives green light to the microtubules ...

located next to the already known motifs of the proteins, are needed," explains Dr. Inna Lermontova, head of IPK's research group Kinetochore Biology. "These binding regions are essential for a ...

But how do chromosomes know where to go? This is the function of the kinetochore, a conserved network of proteins that attach each chromosome to microtubule filaments during chromosome segregation.

“The field has been focused on the role of the Aurora B kinase in phosphorylating kinetochores to help cells fix defective kinetochore-microtubule attachments,” explains Dr. Biggins. In their current ...

In the process, they have discovered how the different kinetochore proteins work together to bind the chromosomes securely to the microtubules. Cell division is vital for the continuation of life.

Scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. The kinetochore is vital to proper DNA ...

Here lies the kinetochore, a complicated assembly of proteins that binds to thread-like structures, the microtubules. As mitosis progresses, the kinetochore gives green light to the microtubules ...

FINDINGS: Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. RELEVANCE ...