With over 15 years of experience in kinase drug discovery, DiscoverX offers the largest collection of nearly 500 biochemical and cell-based kinase assays. KINOMEscan® technology, our novel kinase ...

For example, 45 human protein kinases lack at least one of the conserved catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected for several CDK-related ...

The approval of two kinase-targeting drugs, Genentech's trastuzumab (Herceptin®) in 1998 and Novartis's imatinib (Gleevec®) in 2001, and their success as cancer therapeutics, validate the trend ...