Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer ...

When cancer cells die, macrophages consume them and produce inflammatory cytokines. This activates JAK and STAT proteins in ...

When cancer cells die, macrophages consume them and produce inflammatory cytokines. This activates JAK and STAT proteins in ...

鲁索利替尼通过广泛抑制 jak-stat 信号、调控中性粒细胞活化及 netosis，为难治性 aosd-mas 患者提供了显著的临床疗效，为这类危及生命的炎症性疾病开辟了新的治疗方向。同时，研究发现的 jak-stat 通路功能性变异位点，为未来个体化治疗策略的开发奠定了基础。

近年研究发现，巨噬细胞在ipf中扮演着"双面角色"：早期表现为促炎表型（m1型），分泌tnf-α、il-6等加剧炎症；后期则转化为促纤维化表型（m2型），通过分泌spp1、arg-1等因子激活肌成纤维细胞。这种极化转换受jak-stat信号通路精密调控，但具体机制尚未阐明。

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and ...

The downstream effectors of JAK signaling in hematopoietic cancer include the PI-3 kinase and Ras pathways and the STAT transcription factors. 33 The JAK2 V617F mutation does not cause ...

This analysis revealed that macrophages showed the highest expression of interferon-driven proteins, ... In the JAK/STAT pathway investigation, six proteins—WARS1, STAT1, S100A9, ...

We also found that the transcriptional activity of non–JAK-STAT–dependent pathways that have been implicated in sarcoidosis pathogenesis, including mTORC1 and TNFα, was down-regulated by ...