Isocitrate lyase (ICL ... Given its potential as a drug target against persistent infections, we solved its structure without ligand and in complex with two inhibitors. Covalent modification ...

Figure 1: The overall structure of AceK. Figure 2: The ATP-binding site and the allosteric AMP-binding site in AceK. On the basis of the structural and mutagenesis studies, we rationalize the ...

Somatic monoallelic single nucleotide variants in the genes that encode isocitrate dehydrogenase ... progenitor cells by altering the chromatin structure (through broad DNA and histone ...