Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether ...

Long-term study reveals that multiple islet autoantibodies in young children indicate a high risk of developing type 1 diabetes within 10 years, clarifying the window for potential prevention ...

Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study. Lancet Child Adolesc Health . 2023;7(4):261-268. doi:10.1016/S2352 ...

Additionally, islet autoantibody positivity at the beginning of both optimal test ages was highly predictive of T1D diagnosis in the subsequent age intervals of 2 and 5.99 years and 6 and 15 years.

Children with multiple islet autoantibodies - biological markers of autoimmunity -- are more likely to progress to symptomatic type 1 diabetes (T1D) than those who remain positive for a single ...

Islet autoantibodies play an essential role in the prediction of type 1 diabetes (T1D). [ 1–3 ] These autoantibodies can appear as early as 6–9 months of age and usually precede clinical ...

Among the 4146 children without islet autoantibodies, seroconversion to persistent, confirmed positivity for islet autoantibodies occurred in 40 (1.0%; 95% CI, 0.7 to 1.3).

A dozen volunteers with severe type 1 diabetes showed clear improvements in their condition 12 months after receiving a ...

Islet Autoantibodies Predict Type 1 Diabetes Progression Most children genetically at risk of developing type 1 diabetes will develop the disease if they seroconvert to multiple islet ...

The association between SARS-CoV-2 antibodies and development of islet autoantibodies was most pronounced at age 12 to 16 months. For these children, the incidence rate of developing islet ...

Bonifacio said: “The timing of the islet autoantibody appearance in relation to the SARS-CoV-2 infection in these children was striking. “The most remarkable finding, however, was that the ...