Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether ...

Long-term study reveals that multiple islet autoantibodies in young children indicate a high risk of developing type 1 diabetes within 10 years, clarifying the window for potential prevention ...

Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study. Lancet Child Adolesc Health . 2023;7(4):261-268. doi:10.1016/S2352 ...

Additionally, islet autoantibody positivity at the beginning of both optimal test ages was highly predictive of T1D diagnosis in the subsequent age intervals of 2 and 5.99 years and 6 and 15 years.

Among the 4146 children without islet autoantibodies, seroconversion to persistent, confirmed positivity for islet autoantibodies occurred in 40 (1.0%; 95% CI, 0.7 to 1.3).

A dozen volunteers with severe type 1 diabetes showed clear improvements in their condition 12 months after receiving a ...

Elevations in blood glucose before and after the appearance of islet autoantibodies in children. Journal of Clinical Investigation , 2022; 132 (20) DOI: 10.1172/JCI162123 Cite This Page : ...

Islet Autoantibodies Predict Type 1 Diabetes Progression Most children genetically at risk of developing type 1 diabetes will develop the disease if they seroconvert to multiple islet ...

The association between SARS-CoV-2 antibodies and development of islet autoantibodies was most pronounced at age 12 to 16 months. For these children, the incidence rate of developing islet ...

Bonifacio said: “The timing of the islet autoantibody appearance in relation to the SARS-CoV-2 infection in these children was striking. “The most remarkable finding, however, was that the ...

Islet autoantibodies are linked with the development of type 1 diabetes, and can appear in the blood years, or sometimes decades, before people begin to experience any symptoms.