Historically, LPO and iron-catalyzed free radical generation were central to understanding DILI, but the focus shifted toward apoptosis in the late 20th century. The discovery of ferroptosis—a ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

They demonstrated that melanoma cells induce ferroptosis in osteocytes through the upregulation of HMOX1, a gene involved in ...

Ferroptosis, characterized by iron-mediated lipid peroxidation, holds the potential to counter resistance by selectively targeting cancer cells' defense mechanisms, paving the way for new ...

"Iron overload in the oligodendrocytes is an inducer of ferroptosis in aged brains," the researchers wrote. The researchers found that increased levels of aerobic exercise in the aging rats ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

Glaucoma is a complex and multifactorial neurodegenerative disorder primarily characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual ...

More information: R.C. Gutierre et al, Tau, amyloid, iron, oligodendrocytes ferroptosis, and inflammaging in the hippocampal formation of aged rats submitted to an aerobic exercise program ...