Figure 1: All superfamilies of cellular receptors can be allosterically modulated. Each class of receptors interacts with specific signaling molecules. Upon binding a ligand, the conformation of a ...

Retinoids and steroids exert their biological functions by binding to soluble intracellular receptors of the steroid hormone receptor superfamily; the hormone–receptor complex then acts as a ...

As these hormone binds to their receptor, a cascade of reactions is ... messengers inside the plasma membrane which carry out intracellular signal transduction to convey the effects of the ...

Resistance to endocrine therapy in breast cancer is associated with activation of the mammalian target of rapamycin (mTOR) intracellular ... in 724 patients with hormone-receptor–positive ...

In the study, D2LR is localized to an intracellular compartment such as early endosome in neurons. The growth hormone receptor (PDFGβR) mediates the intracellular localization of the dopamine ...

Semaglutide, a synthetic analog of glucagon-like peptide-1 (GLP-1), has garnered attention for its intriguing properties and potential implications in various r ...

several different types of intracellular receptors are involved in different signaling pathways within the cell. Nuclear receptors, which are also known as nuclear hormone receptors, are activated ...

She describes her research as the study of “intracellular traffic control”—the study of how proteins known as nuclear receptors move in and out of the cell’s nucleus. Allison’s lab focuses on the ...

We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R ... IgG to block the intracellular generation of cAMP ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range ... and why they are such attractive therapeutic targets. GPCRs have an intracellular carboxyl (C) ...