This Review examines the current evidence supporting a role for intracellular amyloid-β (Aβ) in the pathogenesis of Alzheimer's disease. Intracellular Aβ accumulation appears to be an early ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Furthermore, several genetic diseases that directly affect the intracellular sorting and transport machinery were identified (Table 1). This review summarizes our current understanding of the ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

On the other hand, the most current targeted chemotherapies against tumor-specific intracellular oncotargets or mutated genes cause off-target side effects and drug resistance. Importantly ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, ...

But in 2008, Mukherjee stumbled across a new and much faster way to cause intracellular mayhem. Studying bacterial interactions with actin is still throwing up new mysteries. These microbes all enjoy ...

Cardiotoxicity of immune checkpoint inhibitors: A retrospective cohort study of 93,362 patients. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not include a ...

Cell membranes are barriers that maintain cellular homeostasis, and the intracellular delivery of biologically functional molecules, including peptides, proteins, and nucleic acids to manipulate ...

In a study published in Cell Stem Cell, Will and her colleagues showed that young mouse hematopoietic stem cells tightly regulate iron homeostasis to keep intracellular iron levels low, a capacity ...

We aim to understand how nanoparticles deliver biological drugs inside cells, and use these understanding to develop new nanomedicine for novel biotherapeutics. Our research topics are at the ...