Here we demonstrate that AIDS-KS cells express surface interleukin-4 (IL-4) receptors, and that IL-4 toxin (IL-4(38-37)-PE38KDEL) is specifically cytotoxic to these cells. Intratumoral ...

In addition, various cytokines and growth factors produced by these cells, such as interleukin (IL)-4 (Leonard et al, 1997; Shi et al, 1998a), IL-5 (Shi et al, 1998b; Till et al, 1998), IL-10 ...

The FDA approved Dupixent for the treatment of adults with bullous pemphigoid, a rare skin disease often uncontrolled with ...

This pathway is inhibited by interferon-γ and interleukin-4. The transcription factor (T-bet, ROR-γt, or GATA3) characteristic of each pathway is shown. R denotes receptor. Interleukin-23 can ...

Image Credit: ACROBiosystems The biological and immunological functions of B-lymphocytes, monocytes, dendritic cells, and fibroblasts are all affected by the cytokines IL-4 and IL-13. These ...

The Food and Drug Administration (FDA) has approved Dupixent ® (dupilumab) for the treatment of adult patients with bullous pemphigoid.

This approval marks the eighth disease indication for Dupixent as a new alternative for patients—many of whom are elderly and ...

Interleukin-31 may play a role in the pathobiologic ... or 2.0 mg per kilogram of body weight) or placebo every 4 weeks or an exploratory dose of 2.0 mg of nemolizumab per kilogram every 8 weeks.

including interleukin-2 (IL-2) IL-4, IL-7, IL-9, IL-15 and IL-21. Amongst members of the γc family, IL-15 shares many of the same biological activities to IL-2, as they bind common hematopoietic ...