The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

Both integrin-stimulating materials (α3/α5β1 and αvβ3) allow for sprouting from beads. Sprouting into α3/α5β1-stimulating matrices leads to formation of organized, space-filling ...