The α-subunits of integrins — transmembrane adhesion proteins — associate with particular ... of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic ...

Integrins, which are a building block of complex life, are found at the outer edge of cells and encourage proteins to assemble around them when they interact with the outside environment. The team ...

For example, the loss of proteins with 30 or more potential interactions (such as integrin receptors) results in embryonic lethality in mice, whereas the loss of proteins with fewer than seven ...

Cooper’s team imaged adhesion formation at the cell surface interface using total internal reflection (TIRF) microscopy and observed that activated Cas clustered at this site almost a full minute ...