involving the stabilization of the insulin molecule to make it bioavailable in the dry powder form. It was the first insulin product that did not need to be injected, so when it was approved in ...

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features of the metabolic syndrome. Because insulin resistance is associated with cardiovascular disease ...

Researchers have discovered a novel approach to protecting insulin-producing beta cells ... identify and develop small molecules -- termed "molecular glues" -- that enhance the interaction between ...

These include ensuring the stability of the insulin molecule, fine-tuning the glucose sensitivity, and conducting extensive ...

Scientists at Eindhoven University of Technology, among others, have developed a promising method to protect the cells in the ...

It is obtained by inverting of the lysine at position 28 and the proline at position 29 on the ß-chain of the insulin molecule: it confers a conformational change that results in a quick ...

Based on the molecular mimicry hypothesis, the team identified 17 microbialpeptides very similar to insulin B:9-23. Testing them in immune cells obtained from type 1 diabetes patients, they identified ...

In February Nature Medicine, Ellen Air and colleagues from University of Cincinnati College of Medicine, Cincinnati, Ohio, show that small molecule insulin mimetics can reduce food intake and body ...