In mouse thymocytes, positive regulation of inducible T cell kinase (ITK) membrane recruitment by InsP 4 establishes a feedback loop of phospholipase Cγ1 activation downstream of the T cell ...

In the mid 1980s we discovered a phosphatidylinositol kinase that co-purified with several oncoproteins and that correlated with cell transformation ... turnover pathway that uses PI 4-kinase. 1 With ...

Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth ...

Yet “something was missing,” according to coauthor Jay Tan, a cell biologist at the University of Pittsburgh. Up to 90 percent of lysosomal damage is fixed even when the ESCRT complex is inhibited, ...

To maintain homeostasis, intestinal epithelial cells (IECs ... protein folding and degradation. This pathway is mediated by ...

Oxytocin binds to oxytocin receptors on the cell surfaces of uterine muscle. Once bound to these receptors, oxytocin activates the phospholipase C-inositol pathway, which results in the release of ...