As both disorders are characterized by gating deficits, we tested the effects of TPM on the behavioral paradigm of prepulse inhibition (PPI) of the acoustic startle response, a validated animal ...

SGLT-2 inhibitor use vs DPP-4 inhibitor use was associated with lower incidence of epilepsy among patients with type 2 diabetes.

Preclinical findings have shown matrix metalloproteinase 7 (MMP-7) inhibition confers antifibrotic effects and thus, is a promising therapeutic strategy to treat idiopathic pulmonary fibrosis (IPF).

(Nasdaq: ARTL), a clinical-stage pharmaceutical company focused on modulating lipid-signaling pathways to develop treatments for people living with cancer, pain, dermatological or neurological ...

Pretreatment with acetaminophen did not alter the antiplatelet effect of aspirin. The inhibition of serum thromboxane B 2 was similar on day 6 regardless of whether subjects had taken aspirin or ...

Decreased high-density lipoprotein (HDL) cholesterol levels constitute a major risk factor for coronary heart disease; however, there are no therapies that substantially raise HDL cholesterol levels.

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using ...

Condition effects were detected with greater pain relief immediately from isometric contractions: isometric contractions reduced SLDS (mean±SD) from 7.0±2.04 to 0.17±0.41, and isotonic contractions ...

The inhibitory effects lead to increased sodium and urine excreted, reduced resistance in kidney blood vessels, increased venous capacity, and decreased cardiac output, stroke work, and volume.

The three approved PARP inhibitors share several common adverse effects because of a class effect including nausea, fatigue, and anemia, but there are notable differences likely because of variations ...

More data is needed to know how these medicines affect pregnancies. The most serious side effect of SGLT2 inhibitors is a greater chance that you could get diabetic ketoacidosis, a condition that ...