Such immunogens could potentially also neutralize other variants and coronaviruses. When infected by viruses, either by natural infection or vaccination, the human immune system responds by ...

In the present study, researchers designed immunogens against the SARS-CoV-2 spike (S) glycoprotein using computational methods, including scaffolding and structure-guided epitope grafting.

These responses include non-neutralizing antibodies, polyfunctional CD4+ T cells that express two or more cytokines, and CD8+ T cells that recognize a variety of HIV-1 immunogens. To address the ...

Unlike mature VRC01 antibodies, their inferred germline precursors are unable to bind and neutralize HIV, hindering experimental induction of effective bNAbs by HIV immunogens. The binding of germline ...

Researchers identified two HIV-1 Envelope immunogens that elicit broadly neutralizing antibodies when introduced as a vaccine. Seattle BioMed researchers identified two HIV-1 Envelope immunogens ...

A research team has now achieved promising results. Using epitope-focused immunogens, they were able to induce broadly neutralizing antibodies (bnAbs) in laboratory models for the first time.

“This vaccine will protect you against the different strains that are out there.” Swine vaccinated with the immunogens designed in Weaver’s laboratory exhibited no signs of illness after being exposed ...

To demonstrate TopoBuilder’s abilities, Correia and colleagues generated three epitope-focused immunogens designed to induce a targeted neutralizing antibody response to RSV. “In both mice and ...

Swine vaccinated with the immunogens designed in Weaver’s laboratory exhibited no signs of illness after being exposed to a commonly circulating flu strain; developed antibodies against a ...

January 24, 2013 — Seattle BioMed researchers identified two HIV-1 Envelope immunogens that elicit broadly neutralizing antibodies when introduced as a vaccine. The study was published online in ...