Deciduous Therapeutics is developing a novel class of immuno-therapies designed to systemically clear senescent cells and to treat co-morbidities of aging. The gradual accumulation in tissues and ...

A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age. After a year teaching an algorithm to differentiate between the ...

Evidence points to neoantigens as promising T cell targets to drive regression of cancer in patients receiving immuno-oncology ... underpinned by evidence that senescent T cells accumulate as ...

Studying how and why these spurious transcripts are produced in senescent cells as well as their impact on the cell itself could hold important implications for aging and longevity ...

Traditional methods for detecting senescent cells, such as β-galactosidase staining and immunohistochemistry, have limitations in terms of specificity and sensitivity. The introduction of ...

In the course of their study, the researchers found that diseases associated with aging and obesity are triggered and progress when senescent cells accumulate in internal organs, blood vessels and ...

In a paper for Nature Communications, Mark Sanborn and co-authors from the College of Medicine announced the open-source tool to find aging -- or senescent -- cells in organs and tissues.