Accumulating evidence has revealed that epigenetics is critical in understanding the basic molecular mechanisms that take place in chromatin (transcription, splicing, replication and DNA repair ...

By using the TALO8 system, we have identified a unique pattern of acetylations specifically on histones flanking an origin of DNA replication. Our analyses have revealed that the two classes of ...

2024.07.017]. The scientists determined that Mrc1 and Mcm2 form a co-chaperone complex, ensuring distribution of histones to the lagging strand during DNA replication. In mutants of Mrc1 ...

Scientists have sorted out another piece of the DNA replication puzzle by showing what might happen to histones through the process of unwinding DNA. The linkurl ...

The histone chaperone, Asf1, coordinates the removal of histones from the chromatin to allow the replication machinery to move along the DNA, with the supply of new histones to reform the ...

Chances are you've seen an illustration of DNA's double-helix structure and even pictures of the chromosomes ... The DNA is wrapped around histones -- protein structures that are sometimes ...

(Nanowerk Spotlight) Proteins that bind to specific sites of DNA are essential to all biological functions of DNA. These DNA-binding proteins include transcription factors which modulate the process ...

In mitosis, DNA replication is initiated through the actions ... Holliday junctions are targets for many regulatory proteins, such as histones H1 and H5, topoisomerase IIβ, high mobility group ...

both replication processes worked independently without interference. The mirror-image polymerase could also transcribe mirror-DNA into mirror-RNA, again at a glacial pace. The work is published ...

"Essentially, all histones are going away during DNA replication and new histones, which are not modified, are coming in," said Alexander M. Mazo, Ph.D., professor of Biochemistry and Molecular ...