You have full access to this article via your institution. The details of IRF-7 activation remain unclear. Honda et al. do, however, offer an interesting explanation for how pDCs, and not other ...

Figure 1: Trafficking of CpG ODNs in DCs. Figure 2: Subcellular localization of MyD88 and IRF-7, and trafficking of CpG ODNs in a macrophage cell line. Figure 3: High production of type-I IFN in ...

IRF-3 and IRF-7 [46,85,86,88] Defects in type I interferon signaling pathway Deletion of IFNR1, decreased phosphorylation of STAT1 and STAT2, decreased expression of ISGs [46,84,87] Vaccine ...