Figure 4: Deficiency of IL-12/IL-23 signaling in the radio-resistant compartment or peripheral p40-antibody treatment reduces Aβ plaque load in APPPS1 mice. Figure 5: Intracerebroventricular ...

IL-12 binding to interneurons causes them to ... and nerve fiber density changed depending on whether the IL-12 signaling pathway was present or absent. Mass spectrometric analyses (lipidomics ...

Researchers from Charité – Universitätsmedizin Berlin and the Max Delbrück Center have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to ...

(ii) how does IL-7 signaling interact with TCRs to activate ... in B lymphocytes is also dependent on IL-7/STAT5 pathway activation 12, does the IL-7/NFATc1 pathway also exert any influence ...

IL-12 binding to interneurons causes them to ... and nerve fiber density changed depending on whether the IL-12 signaling pathway was present or absent. Mass spectrometric analyses (lipidomics ...

One such messenger is interleukin-12 (IL-12). Through meticulous analyses ... nerve fiber density changed depending on whether the IL-12 signaling pathway was present or absent.

IL-12 binding to interneurons causes them to ... and nerve fiber density changed depending on whether the IL-12 signaling pathway was present or absent. Mass spectrometric analyses (lipidomics ...

It also activates the STAT4 pathway in T cells ... including CD4+ TCR-mediated promotion of IL-12 signaling to induce IFN-γ and peptide-mediated NK cell activation. This leads to tumor lysis ...

Specifically, butyrate treatment was shown to directly boost the antitumor cytotoxic CD8+ T-cell responses both in vitro and in vivo in an ID2-independent manner by promoting the IL-12 signaling ...

A study just published in the journal Nature Cardiovascular Research has clarified important mechanisms in the signaling pathways involved. "We know from our previous work that a genetic ...