Hypoxic exposure leads to an increase in ET-1 release by pulmonary endothelial cells that acts by a paracrine mechanism on adjacent vascular smooth muscle cells to cause vasoconstriction and ...

ETA receptors mediate vasoconstriction, whereas ETB receptors clear endothelin-1 in the splanchnic ... Bosentan Decreases Pulmonary Vascular Resistance and Improves Exercise Capacity in Acute Hypoxia.

The small resistance pulmonary and fetoplacental arteries demonstrate hypoxic vasoconstriction, optimizing oxygen transfer in the lung and placenta. The ductus arteriosus, by contrast, contracts ...

a phenomenon known as hypoxic pulmonary vasoconstriction," explained Dr. Martínez. Several of the study findings provide important information about cell physiology. First, the study shows that ...

Hypoxia induces vasodilation in systemic vessels, but it induces vasoconstriction in the pulmonary vasculature. The acute effect of hypoxia is regulated, in part, by two endothelial cell–derived ...

https://doi.org/10.4103/2045-8932.78098 • https://www.jstor.org/stable/10.4103/2045-8932.78098 AbstractAlthough hypoxic pulmonary vasoconstriction is a well ...

Abdominal organs displace the posterior diaphragm superiorly, exacerbating posterior lung collapse.8 Defective hypoxic pulmonary vasoconstriction may also contribute to ventilation/perfusion (V/Q) ...

hypoxic pulmonary vasoconstriction and activation of peripheral chemoreceptors. These physiological responses can have downstream effects, including sympathetic activation, which increases BP and ...

Phosphodiesterase type 5 (PDE5) inhibitors like sildenafil citrate may prevent intrapartum fetal distress. The results contradict an earlier study that indicated benefits with PDE5 inhibitors; further ...