本综述深入探讨了缺氧（Hypoxia）、肿瘤干细胞特性（Cancer Cell Stemness）与药物耐受性（Drug Resistance）之间的复杂关系，揭示了其在肿瘤治疗中的关键作用。 肿瘤微环境中的缺氧是实体瘤的常见特征，与肿瘤的侵袭性、复发和治疗耐受性密切相关。缺氧能够诱导 ...

The impact of transient hypoxia on metabolic reprogramming was investigated in 3T3-L1 cells before and after differentiation. Glucose uptake, fatty acid oxidation, lipolysis and mitochondria were ...

Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis and release of circulating natriuretic peptides and their derivatives. While one of the most ...

"However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells." The UAB researchers found that HIF1α-glycolysis is indispensable for ...

Hypoxia arises as tumors grow rapidly, outpacing their blood supply due to the lack of an efficient vascular system within ...

Yet for decades the precise workings were largely a mystery. Scientists knew that in low oxygen situations, or hypoxia, cells trigger a cascade of physiological events to restore oxygen ...