However, the high osmolarity of hypertonic saline relative to other plasma expanders confers an additional advantage. With an intact blood-brain barrier, hypertonic saline should pull edematous ...

Am J Health Syst Pharm. 2010;67(22):1920-1928. Due to the high osmolarity of hypertonic saline, infusion through a central line is preferred to minimize phlebitis. Most studies used a 7.5% ...

The serum osmolarity can be used as a surrogate measure of the effect of therapy with either mannitol or hypertonic saline. The initial target is an osmolarity of 300 to 320 mOsm per liter ...

recently led a phase 2 study of idrevloride in hypertonic saline in people with primary ciliary dyskinesia (PCD). Their results, which were published in The Lancet Respiratory Medicine ...

"More importantly, heterologously expressed TMEM63B is activated by hypertonic stimuli ... purified TMEM63B in liposomes exhibits osmolarity-gated currents. Finally, Tmem63b knockout mice have ...