Incompatibility between 1 and Lom6 might explain those observations, but it is also possible that epoxy hydrolysis catalysed by Lom6 is coupled with dehydration in the lomaiviticin biosynthesis ...

Using NMR to follow the reaction process, Shi, et al. first tested acid hydrolysis using DCl added to D 2 O in a solution containing diester and the cavitand. One end of the ester is deep within ...