For example, researchers at Merck screened a library of α-keto heterocyles, a chemotype known to inhibit serine hydrolases 16,206, to obtain a starting point for the development of PRCP ...

Serine hydrolases are one of the largest and most diverse enzyme classes in eukaryotic and prokaryotic proteomes, representing about 1% of all human proteins, reports Benjamin F. Cravatt III, Ph.D ...

“Deploying high-resolution structures and sophisticated mechanistic models, our scientific team at Nura Bio has validated a conserved, NAD-dependent mechanism of inhibition of NAD hydrolases ...