Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought.

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought.

While epilepsy is one of the most common neurological disorders—affecting approximately 1 percent of the population ... in each of the three hyaluronan synthase genes (Has1, Has2, Has3).

We demonstrate that TGFβ potently stimulates hyaluronan synthesis via upregulation of hyaluronan synthase 2 (HAS2 ... using the EMT marker ZO-1. Furthermore, real-time PCR analysis of the ...

Abstract and Introduction Aberrant Splicing of Hyaluronan Synthase 1 in Waldenström's Macroglobulinemia Genetic Variations in Genomic DNA Might Promote Splicing Within HAS1 Sequential Acquisition ...

By intensive sequencing of the hyaluronan synthase 1 (HAS1) gene in malignant and normal cells from patients with WM, we have identified both types of mutation in HAS1 exons and introns.

Their study has also identified that this process is mediated by the induction of hyaluronan synthase 3 (HAS3) expression. In Japan, cadmium is well known as the causative agent of Itai-itai ...