More information: Thai B. Nguyen et al, Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification, Nature Neuroscience (2025). DOI: 10.1038 ...

The cumulative death of many such cells leads to the symptoms of Huntington's disease ... molecular therapy might slow down DNA-repeat expansion by allowing other less error-prone DNA-repair ...

has now revealed a possible molecular mechanism explaining how the DNA repeats are broken and then expanded in the Huntington's disease gene. Freudenreich and her research team report the results ...

The cumulative death of many such cells leads to the symptoms of Huntington's disease ... molecular therapy might slow down DNA-repeat expansion by allowing other less error-prone DNA-repair ...

New genetic research shows why some people develop deadly Huntington's disease earlier than others. The findings could lead to better treatments.

For many people, the symptoms of Huntington's disease will not begin to show for ... Professor Hatters said the exact mechanism of how cells were degenerating or dying was still unknown, it ...

Researchers have made a major breakthrough in our understanding of Huntington's disease. This genetic disorder has long been known to be caused by mutations in the huntingtin gene, which leads to the ...

The field of Huntington’s disease research has been undergoing a radical reshaping of how the brain-ravaging disease — and what drives it — is understood. After decades focused on the notion ...

Huntington’s disease is horrible ... is that the accepted explanation of how Huntington’s plays out at a molecular level is incorrect. That may have led drug companies up a blind alley.

Scientists are unraveling the mystery of what triggers Huntington’s disease, a devastating and fatal hereditary disorder that strikes in the prime of life, causing nerve cells in parts of the ...