Researchers have identified molecular mechanisms affecting RNA processing in Huntington's disease (HD), linking it to other neurodegenerative disorders like ALS and Alzheimer's.

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other ...

More information: Thai B. Nguyen et al, Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification, Nature Neuroscience (2025). DOI: 10.1038 ...

Potential new therapeutic targets for Huntington's disease Molecular mechanisms revealed that drive RNA processing defects leading to disorder Date: January 8, 2025 Source: University of ...

The cumulative death of many such cells leads to the symptoms of Huntington's disease ... molecular therapy might slow down DNA-repeat expansion by allowing other less error-prone DNA-repair ...

Huntington’s disease is horrible ... is that the accepted explanation of how Huntington’s plays out at a molecular level is incorrect. That may have led drug companies up a blind alley.

New genetic research shows why some people develop deadly Huntington's disease earlier than others. The findings could lead to better treatments.

has now revealed a possible molecular mechanism explaining how the DNA repeats are broken and then expanded in the Huntington's disease gene. Freudenreich and her research team report the results ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...