In Huntington’s disease, a genetic error leads the protein huntingtin to form clumps in the brain, leading to involuntary ...

Multi-epitope immunopurifications of huntingtin (HTT) from vulnerable brain regions of Huntington’s disease (HD) models ...

Huntington's disease occurs when expanded, exon 1–encoded polyglutamine domains in huntingtin (Htt) undergo a conformational switch to form amyloid aggregates. Previous work established that the ...

These expanded huntingtin proteins aggregate inside cells and damage them in various ways, although exactly how this results in the death of nerve cells remains uncertain. Spearheaded by graduate ...

The distinct protein aggregates that are found in Alzheimer ... involved in type II diabetes), huntingtin with extended polyglutamine stretches (involved in HD) and the prion protein (PrP ...

This shows huntingtin protein aggregates under an atomic force microscope. Scale bar, 500 nm. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...

They include the dysregulation of the expression of thousands of genes in the striatal neurons and an accumulation of clumps of mutant Huntingtin protein (called aggregates), which are a hallmark ...