In the mouse model and human tumor samples, MAGE-A4 drives the accumulation of plasma immune cells that suppress antitumor immunity. The study points at novel potential therapeutic avenues that ...

MAGE-A4 is expressed in human NSCLC and is associated with loss of PTEN. Credit: Science Advances (2025). DOI: 10.1126/sciadv.ads4227 ...

A phase I/II first-in-human study of a novel anti-MAGE-A4 TCR/anti-CD3 bispecific (IMC-C103C) as monotherapy and in combination with atezolizumab in HLA-A*02:01-positive patients with MAGE-A4-positive ...

Researchers at Baylor College of Medicine and collaborating institutions discovered in a mouse model of non-small cell lung cancer that tumors that express protein MAGE-4 and have lost the Pten ...

News Medical. Study uncovers how ... In the current study, we investigated the malignant potential and immunological roles of MAGE-A4 in mouse and human non-small cell lung cancer." ...

Now, a team of scientists from Harvard Medical School and MIT have found a way to do similar trick ... In every human, ... That includes the one that introduced MAGE to the world in 2009, ...