One involves studying the effect of a 'candidate' gene on a phenotype; for example, using transgenesis or homologous recombination (creating 'knockout' or 'knockin' mice). The other entails using ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Both gene knockout and knock-in models are powerful ... or nonhomologous end-joining (NHEJ). Historically, homologous ...

DSBs arise from agents, such as ionizing radiation, and can also occur spontaneously during DNA replication. Our emphasis is on repair of DSBs by homologous recombination, with a particular interest ...

including the generation of a Setd2-CD knockin mouse model through homologous recombination technology, followed by a comparative analysis with the existing Setd2 knockout model. The Setd2-CD mice ...