One involves studying the effect of a 'candidate' gene on a phenotype; for example, using transgenesis or homologous recombination (creating 'knockout' or 'knockin' mice). The other entails using ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Although the use of homologous recombination in stem cells currently lags behind the use of zinc fingers for creating knockout rats, it might allow researchers to reliably introduce genes into ...

Gene knockout models involve the deliberate ... or nonhomologous end-joining (NHEJ). Historically, homologous recombination ...

The investigation involved a comprehensive approach, including the generation of a Setd2-CD knockin mouse model through homologous recombination ... genes in both Setd2-CD and Setd2 knockout ...