The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...

In metazoans, an additional histone, termed histone H1 ... that results from the induction of approximately one negative supercoil for each nucleosome that is assembled 35. A series of reactions ...

When attached to specific amino acid side chains on a histone's tail, these chemical tags recruit proteins that change the local chromatin structure and, consequently, the accessibility of genomic ...

The modifications impact this gene expression by changing the structure of chromatin or through recruitment of histone modifiers. Histones pack DNA into structures called nucleosomes, to fit the ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

This article describes the histone western blot protocol, which is often used at Abcam for identifying histone proteins obtained from purified calf thymus. For each lane, either 0.5 μg of calf ...

In a recent study, the question of histone inheritance was addressed by scientists based at the University of Copenhagen. These scientists, led by Professors Anja Groth and Geneviève Thon ...

This enzyme is able to silence specific DNA sections by epigenetically modifying histone proteins that package the DNA. These modifications ensure that the DNA is densely packed as heterochromatin ...

Researchers have completed a comprehensive analysis of cancer-associated histone mutations in the human genome, featuring both biochemical and cellular characterizations of these substrates.

We asked whether there is a link between the severity of disease and the reduction in histone deacetylase (HDAC) activity in the peripheral lung tissue of patients with COPD of varying severity.