DNA methylation and histone modification influence each other during development. Histone methylation can help to direct DNA methylation patterns, and DNA methylation seems to serve as a template ...

Although considerable progress has been made towards understanding the dynamic landscape of histone-methylation regulation, the biological functions of these newly found demethylases are just ...

Using animal models, he, Dempsey, and the rest of their research team found that H3K36 methylation—a biochemical process that ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. Peter Dempsey, PhD, professor of ...

Further analysis revealed that the inversion at the DG1 promoter significantly reduced the repressive histone methylation marks H3K27me3 and H3K9me2, alleviating transcriptional repression and ...

To compact the DNA, plants use various epigenetic marks, including DNA methylation and modifications of the histone proteins that organize and package the DNA. These two marks reinforce each other ...

EZH2, a core component of the Polycomb Repressive Complex 2 (PRC2), plays a fundamental role in silencing tumor suppressor genes through histone methylation. Its overexpression has been implicated ...

Biological processes are also under intensive regulation at the epigenomic level. We aim to understand the functions of DNA methylation and histone modifications in these processes and to provide new ...

Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. GA, UNITED STA ...