The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the ...

Figure 1: Histone H3.3 Ser31 becomes phosphorylated along arms of misaligned chromosomes. To accentuate this difference, we used nocodazole treatment to depolymerize microtubules, allowing the ...

Histone H3 phosphorylation may initiate at different phases of the cell division in different organisms, but metaphase chromosomes are always found to be heavily phosphorylated. Upon exit of ...

Researchers identify a novel centromere-specific histone H3 variant called the “CENP ... Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper ...

Histones are the building blocks of chromatin, the structural support of chromosomes within a cell's nucleus. While histone H3 is particularly abundant in multicellular organisms such as plants ...

Centromeres, specialized regions located at the center of chromosomes ... which contain eight histone proteins—two each of H2A, H2B, H3, and H4. However, centromeres feature a specialized ...

The CENP-A nucleosome is copied several times to create a unique epigenetic area, different from the rest of the chromosome. CENP-A replaces histone H3 in the nucleosomes located at the centromere.

The cell skeleton, which distributes the chromosomes to the two daughter ... epigenetic centromere marking is a variant form of the H3 histone known as CenH3. Histone proteins bind the DNA largely ...

Researchers from Children's Hospital of Philadelphia (CHOP) have demonstrated that newly mutated variants of a key protein involved in supporting chromosomes ... of the H3.3 histone had any ...

function and inheritance of the centromere are determined by the histone CenH3, a DNA packaging protein. This discovery may help to further the development of artificial human chromosomes ...

Independent researchers have identified mutations in the histone H3.3-coding gene H3F3A in a large proportion of pediatric cases of gliobastoma multiforme (GBM) and diffuse intrinsic pontine ...