Disruptions in the regulation of TGF-β and HIPPO pathways contribute to liver diseases. In fibrosis, the TGF-β pathway promotes the activation of hepatic stellate cells, leading to extracellular ...

Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...

In the study, first authors Eva Jahanshir and Juan Llamas from the Gnedeva lab focused on a group of interacting genes called the Hippo pathway, which serve as a "stop growing" signal that the lab ...

In their experiments, the scientists demonstrated that the Hippo pathway also suppresses the regeneration of damaged sensory receptors in the ear and eye of adult mice. The scientists used an ...