In cell-based assays, either hepcidin from hepatocytes or exogenous hepcidin suppresses HSC activation by inhibiting TGFβ1-mediated Smad3 phosphorylation via Akt.

在生命科学的探索中，Hepcidin-25（铁调素，M28234，AbMole）作为铁代谢和免疫反应的关键调节因子，一直是研究的热点。它不仅在基础生物学中扮演着 ...

来自日本INFINITY队列的研究人员针对维持性血液透析患者心血管疾病(CVD)高发问题，通过前瞻性多中心研究评估了血清hepcidin-25的预测价值。采用新型乳胶比浊免疫分析法检测567例患者，发现CVD事件组hepcidin-25水平显著低于对照组(19.0 vs. 37.8 ng/mL，P<0.05)，多因素分析证实低hepcidin-25(OR=0.82,95%CI ...

为解决水产养殖中致病性弧菌感染的防控难题，研究人员从丝鳍银鲈(Gerres filamentosus)中鉴定出一种新型hepcidin异构体(rGf-Hep)，通过膜去极化、膜通透性改变及ROS生成等多重机制，显著抑制副溶血弧菌(V. parahaemolyticus)等病原体，其非细胞毒性特性为开发安全高效的抗弧菌制剂提供新思路。

Protagonist Therapeutics Inc. (NASDAQ:PTGX) is one of the best mid cap growth stocks to invest in now. Just as June began, ...

The VERIFY trial explores rusfertide to manage polycythemia vera without causing iron deficiency symptoms, Dr. Aaron Gerds ...

About the study. The present study used murine models of psoriasis and cell-based experiments to examine the roles of iron ...

Activity and tolerability of cisplatin (CDDP) and fotemustine (FTM) in non-small cell lung cancer (NSCLC) patients (PTS) with brain metastases (BM): A multicentric phase II study of the Gruppo ...

New research highlights how elevated levels of the iron-regulating hormone hepcidin contribute to psoriasis by driving skin cell proliferation and inflammation, offering fresh avenues for therapy.

The recently identified peptide hepcidin is the link between inflammation and anemia and is the reason iron supplements should be avoided in some cases. (McGrath H, Rigby PG. 2004; 43:1323-1325 ...

This over-abundance of the hormone caused the animals' skin cells to retain far more iron than was required. In turn, this excess iron triggered both a hyperproliferation of skin cells and an ...