both unfractionated heparin and low-molecular-weight heparin can inhibit factor Xa. However, the longer polysaccharide chains found in unfractionated preparations are required for the inhibition ...

Purpose. The performance of a weight-based dosing protocol for unfractionated heparin (UFH) infusions using antifactor Xa monitoring was evaluated. Methods. The first 50 patients to receive a UFH ...

The most common methods for monitoring UFH are the activated partial thromboplastin time (aPTT) and antifactor Xa heparin assay (anti-Xa HA), but both present challenges, and the optimal method to ...

need to provide clinicians with a heparin therapeutic range specific for their lot of reagent on their analyzer. An anti-Xa assay is a standardized test that has good precision, and is linear. A ...

Anticoagulants are effective for prevention and treatment of prothrombotic disease states and can be prescribed for parenteral (IV) or oral administration. Several novel, direct acting oral ...

Heparin-induced thrombocytopenia develops in a 57-year-old man who underwent knee ... (factors VIIIa, IXa, and X), and the prothrombinase complex (factor Va, factor Xa, and prothrombin ...

Studies show that factor Xa inhibitors reduce recurrent VTE just as well or better than standard therapies. That includes drugs in the same class, such as low molecular weight heparin (LMWH ...

And it's quite possible that this is just not an anticoagulant effect—this is a heparin effect.” On the other hand, studies of enoxaparin and fondaparinux, which are indirect inhibitors of factor Xa ...

whether it be warfarin during all three trimesters or LMWH during the first trimester with strict anti-Xa monitoring, followed by an eventual change to unfractionated heparin just before delivery.

Overview: Heparin is a blood thinner that is used to prevent or treat blood clots. It may be injected under the skin or into a blood vessel. The most common side effects are irritation at the ...