The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we report the cDNA ...

本研究针对骨髓(BM)与外周血(PB)微循环对骨组织止血平衡的调控机制展开探索。研究人员通过对比BM与PB对成骨细胞和内皮细胞(HUVECs)的作用，发现BM血浆显著降低肝素酶(heparanase)、组织因子(TF)等促凝因子表达，同时增强内皮细胞增殖和血管形成能力。研究首次 ...

上海东方医院团队针对特发性肺纤维化（IPF）缺乏有效疗法的难题，首次揭示肝素酶（heparanase）通过PI3K/Akt-自噬通路促进M2型 ...

Microsatellite instability and loss of PTEN expression in early versus late-stage endometrial cancer: Results from studies of the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG) ...

Once bound, the viruses can enter the cells. In the late stages of infection the virus causes the infected cells to increase production of heparanase, an enzyme involved in the remodeling of the ...

A randomised, placebo-controlled, double-blind phase II study of raltitrexed and gefitinib vs raltitrexed alone as 2nd line chemotherapy in subjects with advanced colorectal cancer (CRC). GON group ...

The cellular protein heparanase plays an important role in allowing diseases, including viruses and cancers, to spread within our bodies. For this reason, researchers investigating a wide range of ...

Once bound, the viruses can enter the cells. In the late stages of infection the virus causes the infected cells to increase production of heparanase, an enzyme involved in the remodeling of the ...

Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of gastric cancers. Although their efficiencies in inhibiting the ...

The UIC team examined how the heparanase protein, which is present in all our cells, affects reinfection from the herpes simplex virus type 1 in mice. They found that inhibiting heparanase ...

This is achieved using a ‘heparanase inhibitor’. Heparanase acts likes a pair of scissors, damaging the glycocalyx lining. Heparanase inhibitors stop this damage from happening. The research team has ...