and degradation? How mitochondrial chaperones interpret signals in their substrate proteins and the cellular environment to control the activities of these proteins is a major outstanding question. I ...

Rhythmic heme degradation, which generates the signaling molecule carbon monoxide, is required for normal circadian rhythms as well as circadian metabolic outputs. Genetic depletion of CO ...

They are thought to be a mixture of heme products, formed during the degradation of red blood cells. These products were only observed in the unstable plaques with internal bleeding and not ...

They are thought to be a mixture of heme products, formed during the degradation of red blood cells. These products were only observed in the unstable plaques with internal bleeding and not ...

Additional research highlights: KTX-582 induced apoptosis in association with IRAK4 degradation in MYD88MT ... preclinical models of STAT3-dependent heme malignancies, including ALK+ ALCL.

myelodysplastic syndromes-related anemia New results highlighting the enhanced immune-stimulating activity and combinability of targeted protein degradation agents in the treatment of relapsed or ...