Erythropoietic protoporphyria and X-linked protoporphyria are inborn errors of heme biosynthesis that cause elevated circulating levels of metal-free protoporphyrin and phototoxicity. Both ...

A mutation that impacts an enzyme involved in heme biosynthesis causes porphyrias, which are inheritable metabolic disorders. There are different types of porphyrias based on the specific enzyme ...

Bitopertin is an investigational, clinical-stage, orally-administered inhibitor of glycine transporter 1 (GlyT1) that is designed to modulate heme biosynthesis. GlyT1 is a membrane transporter ...

The TIBCAS team discovered a unique enzymatic mechanism involving the heme-catalase enzyme EasC, which plays a key role in EA biosynthesis. They found that EasC contains two distinct catalytic ...

“We propose that the need to assimilate and detoxify ammonium from heme biosynthesis and other metabolic processes led to the selective activation of glutamine synthesis as a specialized ...

Bitopertin is a clinical-stage oral medication designed to inhibit glycine transporter 1 (GlyT1) and modulate heme biosynthesis, potentially offering the first disease-modifying therapy for ...